Inzira 3 zishimishije abahanga mu bya shimi bubatse ibice uyu mwaka
na Bethany Halford
ENZYMES YABAYE KUBAKA BIARYL BONDS
Gahunda yerekana enzyme-catisale biaryl guhuza.
Abashinzwe imiti bakoresha molekile ya biaryl, igaragaramo amatsinda ya aryl ahujwe nundi umwe, nka chiral ligands, ibikoresho byubaka ibikoresho, hamwe na farumasi.Ariko gukora motif ya biaryl hamwe nicyuma-catisale reaction, nka Suzuki na Negishi kwambukiranya, mubisanzwe bisaba intambwe nyinshi zo gukora kugirango bafatanye.Ikirenzeho, ibi byuma-catalizike reaction birahungabana mugihe ukora biaryls nini.Itsinda ryayobowe na Alison RH Narayan wo muri kaminuza ya Michigan ryifashishije imbaraga za enzymes zo guhagarika reaction, ryifashishije ubwihindurize ryakozwe mu gukora enzyme ya cytochrome P450 yubaka molekile ya biaryl ikoresheje okiside ihuza amavuta ya karubone-hydrogène.Enzyme irongora molekules ya aromatic kugirango ikore stereoisomer imwe ikikije umurunga hamwe no kuzunguruka (kwerekanwa).Abashakashatsi batekereza ko ubu buryo bwa biocatalytic bushobora guhinduka umugati-n'amavuta yo gukora biaryl (Kamere 2022, DOI: 10.1038 / s41586-021-04365-7).
ICYEMEZO CYA AMINES YA GATATU YISHINGIYE KUMUNTU GATO
Gahunda yerekana reaction ikora amine yo mucyiciro cya kabiri.
Kuvanga ibyuma bya elegitoroniki byashonje hamwe na amine ikungahaye kuri electron mubisanzwe byica catalizator, bityo reagent yicyuma ntishobora gukoreshwa mukubaka amine ya kaminuza kuva amine yisumbuye.M. Christina White na bagenzi be bo muri kaminuza ya Illinois Urbana-Champaign bamenye ko bashobora gukemura iki kibazo baramutse bongeyeho ibirungo byumunyu mubyo bakora.Muguhindura amine ya kabiri mumunyu wa amonium, abahanga mu bya shimi basanze bashobora kubyitwaramo hamwe na olefine ya terminal, okiside, hamwe na catalizike ya palladium sulfoxide kugirango bakore amine menshi ya amine menshi hamwe nitsinda ryimikorere itandukanye (urugero rwerekanwe).Abashinzwe imiti bakoresheje reaction kugirango imiti igabanya ubukana Abilify na Semap no guhindura imiti iriho ari amine ya kabiri, nka antidepressant Prozac, ihinduka amine yo mu rwego rwo hejuru, berekana uburyo abahanga mu bya shimi bashobora gukora imiti mishya mu bari basanzwe (Science 2022, DOI: 10.1126 / siyanse.abn8382).
AZAARENES AMASEZERANO YA CARBON
Gahunda yerekana quinoline N-oxyde yahinduwe N-acylindole.
Uyu mwaka abahanga mu bya shimi bongeye muri repertoire yo guhindura molekile, ibyo bikaba reaction ikora impinduka kumikorere ya molekile igoye.Urugero rumwe, abashakashatsi bakoze impinduka ikoresha urumuri na aside kugirango bakure karubone imwe muri azaarenes igizwe nabantu batandatu muri quinoline N-oxide kugirango babe N-acylindoles hamwe nimpeta zigizwe nabantu batanu (urugero rwerekanwe).Igisubizo cyakozwe n’abahanga mu bya shimi mu itsinda rya Mark D. Levin muri kaminuza ya Chicago, gishingiye ku myitwarire yarimo itara rya mercure, rizimya urumuri rwinshi rw’umucyo.Levin na bagenzi be basanze gukoresha diode itanga urumuri rutanga urumuri kuri 390 nm byabahaye kugenzura neza kandi bibemerera gukora reaction rusange kuri quinoline N-oxyde.Igisubizo gishya giha abakora molekile uburyo bwo kuvugurura ingirabuzimafatizo zikomeye kandi zishobora gufasha abahanga mu by'imiti bashaka kwagura amasomero y’abakandida b’ibiyobyabwenge (Science 2022, DOI: 10.1126 / siyanse.abo4282).
Igihe cyo kohereza: Ukuboza-19-2022